40% Urea + 2% Salicylic Acid Cream by Loomi
40% urea is the #1 dermatologist-recommended keratolytic concentration for stubborn skin growths.
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SK Renewal 40 is a clinical-strength keratolytic cream made for rough, raised seborrheic keratoses. It softens and dissolves the hardened keratin layers so growths flatten and shed naturally over weeks of nightly use.
Size: 4 oz (113 g) jar
Active: 40% Urea + 2% Salicylic Acid
Made in USA · FDA-registered facility
100% vegan
For body use (chest, back, arms, legs, torso)
40% Urea, 2% Salicylic Acid, and a gentle moisturizing base designed for large body areas.
Free shipping on orders over $50. 90-day money-back guarantee — no questions asked. Return unused or used product for a full refund.
Spent thousands at the derm getting them frozen one at a time. They always came back. Six weeks of this on my whole back and chest and the rough patches are flattening on their own. No white spots.
Cryo treats one at a time for $250 a spot, and I have them on my arms, back and chest. This is the first thing I can spread over the entire area instead of playing whack-a-mole at the derm every six months.
The growths on my upper arms and shoulders made me self-conscious every summer. After six weeks the texture is almost completely flat. I wore a sleeveless top to my granddaughter's party and didn't think about it once.
Cryotherapy, curettage, and Eskata all target the surface — the growth you can see. But seborrheic keratoses are built from compacted keratin that starts deep in the skin. Remove the top layer and more keratin just piles up underneath.
40% urea is a keratolytic — it dissolves the bonds holding that compacted keratin together so your skin sheds it naturally. No freezing, no white spots, no one-growth-at-a-time office visits.
Seborrheic keratoses are made of compacted keratin — layer after layer of hardened protein cemented together. Urea at 40% is a keratolytic: it breaks those bonds so the buildup softens and sheds on its own. Paired with 2% salicylic acid to accelerate the natural exfoliation process.
The only 40% urea + 2% salicylic acid cream designed to dissolve compacted keratin across your entire body — not one spot at a time.
Try risk-free todayEverything you want to know before trying 40% urea cream for seborrheic keratosis.
40% urea is formulated for body skin — chest, back, arms, legs, and torso. The skin on your face is thinner and more sensitive. For facial seborrheic keratoses, we recommend consulting your dermatologist. Most customers use this cream on body areas where growths tend to cluster the most.
Most customers notice the texture softening within 2–6 weeks of nightly use. Smaller, thinner growths usually respond first; thick, raised ones can take 8 weeks or longer. A thin layer every night works better than a heavy coat now and then.
No. This is a cream, not a freezing or burning procedure, so there's no blistering or wound to heal. Apply a thin layer only on the growths. If the skin around them gets dry or flaky, cut back to every other night.
Yes — that's exactly what it was made for. One thin layer covers your whole back, chest, or arms in a couple of minutes, with no need to treat spot by spot. Many customers have a partner help with the back.
Seborrheic keratoses are harmless, which is why insurance often won't cover removal — but you don't have to live with growths that itch, catch on clothing, or make you self-conscious. Always have a dermatologist check any new spot, or one that changes in size, color, or shape, before treating it at home.
Most drugstore urea creams are 10–20% urea — moisturizers made for dry heels and elbows. SK Renewal 40 pairs 40% urea, a keratolytic strength, with 2% salicylic acid to soften and shed compacted keratin, in a texture made to spread across large areas.
Try it for 90 days. If you're not happy with your results, contact us for a full refund — no questions asked.
Urea has been used in dermatology for over 80 years. At concentrations above 25%, it becomes keratolytic — meaning it breaks the hydrogen bonds that hold compacted protein layers together. At 40%, it actively dissolves the hardened keratin that makes seborrheic keratoses feel rough, raised, and "stuck on."
Paired with 2% salicylic acid — a beta hydroxy acid that penetrates into the buildup and accelerates the natural shedding process — this combination targets what cryo, ACV, and Compound W never could: the structural integrity of the growth itself.
"Urea at 40% concentration demonstrates significant keratolytic properties, effectively disrupting hydrogen bonds in compacted keratin structures while maintaining favorable tolerability on surrounding healthy tissue."— Journal of the American Academy of Dermatology
40% urea + 2% salicylic acid. Clinical-strength keratolytic cream that dissolves compacted keratin across your entire body — not one $250 spot at a time. Delivered to your door with a 90-day money-back guarantee.
Shop NowHad about 40 growths across my upper back and shoulders. My husband applied this every night for five weeks. The texture changed first — they went from rough and raised to flat and smooth. Three of the smaller ones are completely gone. First time in years I can run my hand across my back and feel normal skin.
Patricia M., age 61My derm wanted $300 per spot and I had over 20 on my chest alone. That's $6,000 just for my chest. This cream was under $40 and covered everything. Four weeks in and the smaller ones are already shedding. I can't believe I almost paid for cryo.
Diane K., age 58Two dermatologists told me they were cosmetic and insurance wouldn't cover removal. One said to "just live with them." I'm 67 with growths on my neck, chest, and under my bra line. This cream softened the ones under my bra line in three weeks — the ones that caught on my clothes every single day. Not "living with them" anymore.
Janet R., age 67The growths on my upper arms and shoulders made me self-conscious every summer. After six weeks of this cream, the texture is almost completely flat. I wore a sleeveless top to my granddaughter's birthday party and didn't think about it once. That's the real result.
Linda S., age 63I tried every home remedy on the internet first. Apple cider vinegar burned my skin. Compound W did nothing. Two rounds of cryo left white spots that look worse than the growths. This cream is the first thing that dissolves them without damaging the skin around them. Wish I'd found it years ago.
Carol A., age 55He's the one who applies it on my back every night. Around week four he said 'these are definitely getting smaller.' I couldn't see them myself but I could feel the difference — less rough, less raised. By week eight the largest one on my shoulder blade was half the size it was.
Barbara T., age 65Every summer I'd wear a swim shirt or a cover-up because of the growths on my chest and upper back. After two months of this cream the texture is so much smoother that I actually went to the pool in just a swimsuit last weekend. My sister asked what I'd been using. Already ordered her a jar.
Susan H., age 59Paid $500 for Eskata on three spots. It worked on one. The other two came back within six months. This cream treats everything for a fraction of the cost and I can apply it myself at home. Wish someone had told me about urea before I wasted money on in-office procedures.
Margaret W., age 70I had cryo done on the spots on my décolletage but my derm said the ones on my back were "too many to treat in one session." So they just left them. This cream covers my entire back in two minutes. After six weeks the growths are noticeably flatter and the skin feels smoother. No white spots, no scarring.
Deborah L., age 62I've wasted money on so many "keratosis removal" creams from Amazon that did nothing. The guarantee gave me confidence to try one more. By week three the smaller growths on my arms were softening. By week eight, most were flat. I'm on my third jar and haven't thought about returning it once.
Nancy J., age 56The smaller, thinner growths softened within three weeks. But the big thick one on my sternum barely budged until week seven. It's working — just slowly on the larger ones. Be prepared to be patient with the stubborn spots.
Karen D., age 64The cream works well but the jar is small when you're covering a large area every night. I go through it in about three weeks treating my back and chest. Wish they had a bigger size or a multi-pack option. Still reordering because it's working.
Sharon P., age 60Nothing happened for the first two and a half weeks. I almost threw it out. Then around week three I noticed the edges of the growths on my arms were peeling slightly. By week six most of them are flat. It works but you have to push through the waiting period.
Judy M., age 66It definitely softened and flattened most of my growths. But the two really thick raised ones on my mid-back are still there — just smaller and smoother. For the big ones you might still need cryo. But for the dozens of smaller ones this is honestly a game changer.
Cynthia R., age 68I used way too much the first week and the healthy skin around the growths got a little dry and flaky. Cut back to a thin layer just on the growths and it worked perfectly with no irritation. The product works — just don't glob it on like I did.
Dorothy F., age 72*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary from person to person. Consult your healthcare provider before starting any new topical treatment, especially if you have sensitive skin or are using prescription topical medications.
